Pervasive satellite cell contribution to uninjured adult muscle fibers

  title={Pervasive satellite cell contribution to uninjured adult muscle fibers},
  author={Bradley T. Pawlikowski and Crystal Pulliam and Nicole Dalla Betta and Gabrielle Kardon and Bradley B Olwin},
  booktitle={Skeletal Muscle},
Adult skeletal muscle adapts to functional needs, maintaining consistent numbers of myonuclei and stem cells. Although resident muscle stem cells or satellite cells are required for muscle growth and repair, in uninjured muscle, these cells appear quiescent and metabolically inactive. To investigate the satellite cell contribution to myofibers in adult uninjured skeletal muscle, we labeled satellite cells by inducing a recombination of LSL-tdTomato in Pax7CreER mice and scoring tdTomato… CONTINUE READING
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Muscle stem cells contribute to myofibres in sedentary adult mice

  • AC Keefe, JA Lawson, SD Flygare, ZD Fox, MP Colasanto, SJ Mathew
  • Nat Commun. 2015;6:7087
  • 2015
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