Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?

@article{Sporn2004PervasiveDD,
  title={Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness?},
  author={Alexandra L Sporn and Anjen{\'e} M Addington and Nitin Gogtay and Anna E. Ord{\'o}{\~n}ez and Judith L. Rapoport},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={989-994}
}
BACKGROUND Childhood-onset schizophrenia (COS) is a severe form of the adult-onset disorder with a high rate of premorbid developmental abnormalities. Early symptoms of pervasive developmental disorder (PDD) have been reported in five independent studies of COS. In this study, we compared evidence for premorbid PDD as a nonspecific manifestation of impaired neurodevelopment seen in schizophrenia, or as an independent risk factor for COS. METHODS Diagnosis of past or current autism or PDD was… CONTINUE READING

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