Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing.

@article{Mustoe2018PervasiveRF,
  title={Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing.},
  author={Anthony M Mustoe and Steven Busan and Greggory M. Rice and Christine E. Hajdin and Brant K. Peterson and Vera M Ruda and Neil Kubica and Razvan Nutiu and Jeremy L Baryza and Kevin M Weeks},
  journal={Cell},
  year={2018},
  volume={173 1},
  pages={181-195.e18}
}
mRNAs can fold into complex structures that regulate gene expression. Resolving such structures de novo has remained challenging and has limited our understanding of the prevalence and functions of mRNA structure. We use SHAPE-MaP experiments in living E. coli cells to derive quantitative, nucleotide-resolution structure models for 194 endogenous… CONTINUE READING