Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation

@article{Kindt1995PertussisTS,
  title={Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation},
  author={Rachel M. Kindt and Arthur D. Lander},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={79-88}
}
An assay employing patterned laminin substrata was used to screen for compounds that disrupt neurite guidance. One molecule, pertussis toxin, caused neurites to wander from patterns that normally guided them, yet had no significant effect on rates of neurite outgrowth. Wandering was greatest on patterns requiring frequent guidance (e.g., laminin stripes with periodic gaps). Surprisingly, the B oligomer of pertussis toxin, which lacks the subunit that inactivates G proteins, was equipotent at… CONTINUE READING

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Structure of a pertussis toxin-sugar complex as a model for receptor binding

  • P. E. Stein, A. Eoodhoo, +5 authors R. J. Read
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