Pertussis toxin pretreatment antagonizes the actions of mu- and delta-opiate agonists in hippocampal slices.

@article{Dunwiddie1988PertussisTP,
  title={Pertussis toxin pretreatment antagonizes the actions of mu- and delta-opiate agonists in hippocampal slices.},
  author={Thomas V. Dunwiddie and Moon Ting Su},
  journal={Neuroscience letters},
  year={1988},
  volume={95 1-3},
  pages={329-34}
}
The effect of pertussis toxin pretreatment on electrophysiological responses to selective delta- and mu-opioid receptor agonists was examined in rat hippocampal brain slices. The evoked population spike response in the CA1 region following activation of the Schaffer collateral and commissural afferents was increased following perfusion with the delta-selective agonist [D-Pen2,D-Pen5]enkephalin (DPDPE), and with the mu-selective agonist [D-Ala2,NMe-Phe4,Gly(O)5ol]enkephalin (DAGO). Both effects… CONTINUE READING

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