Pertussis toxin induces angiogenesis in brain microvascular endothelial cells.

@article{Lu2008PertussisTI,
  title={Pertussis toxin induces angiogenesis in brain microvascular endothelial cells.},
  author={Changming Lu and Steven Pelech and Hong Zhang and Jeffrey P. Bond and Karen M. Spach and Rajkumar Noubade and Elizabeth P. Blankenhorn and Cory Teuscher},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 12},
  pages={2624-40}
}
Pertussis toxin (PTX) is an ancillary adjuvant used to elicit experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis. One mechanism whereby PTX potentiates EAE is to increase blood-brain barrier (BBB) permeability. To elucidate further the mechanism of action of PTX on the BBB, we investigated the genomic and proteomic responses of isolated mouse brain endothelial cells (MBEC) following intoxication. Among approximately 14,000 mouse genes tracked by… CONTINUE READING

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