Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse.

@article{SnchezBlzquez1988PertussisTD,
  title={Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse.},
  author={Pilar S{\'a}nchez-Bl{\'a}zquez and J. Rodŕıguez Garz{\'o}n},
  journal={European journal of pharmacology},
  year={1988},
  volume={152 3},
  pages={357-61}
}
The i.c.v. administration of 0.5 microgram pertussis toxin to mice led to a non-competitive reduction (approximately 60 to 70%) of the supraspinal analgesia evoked by i.c.v. injection of ED90 doses of [D-Ala2,N-MePhe4,Gly-ol5]enkephalin, [D-Ala2,N-MePhe4,Met-(O)5-ol]enkephalin, [D-Ala2,Met5]enkephalinamide, [D-Ala2,D-Leu5]enkephalin or [D-Pen2,D-Pen5]enkephalin, whereas the analgesic effect of ED90 doses of morphine, etorphine, beta-casomorphin-(1-4) amide or human beta-endorphin was reduced to… CONTINUE READING

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