Pertussis toxin B-oligomer dissociates T cell activation and HIV replication in CD4 T cells released from infected lymphoid tissue.

@article{Alfano2005PertussisTB,
  title={Pertussis toxin B-oligomer dissociates T cell activation and HIV replication in CD4 T cells released from infected lymphoid tissue.},
  author={Massimo Alfano and J C Grivel and Silvia Ghezzi and Davide Corti and Matteo Trimarchi and Guido Poli and Leonid Margolis},
  journal={AIDS},
  year={2005},
  volume={19 10},
  pages={1007-14}
}
OBJECTIVE To investigate, in human lymphoid tissue infected with HIV-1 ex vivo, the immunostimulatory and HIV inhibitory properties of pertussis toxin B oligomer (PTX-B) and of the genetically modified non-toxic PT-9K/129G. METHODS Human tonsils from uninfected donors were infected ex vivo with R5 or X4 HIV-1 in the presence or absence of PTX-B. Virus replication was evaluated in culture supernatants; cells emigrated from tissue blocks were immunostained for lymphocytic and activation markers… CONTINUE READING

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