Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin.

  title={Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin.},
  author={F. Mooi and N. A. T. VAN DER MAAS and H. De MELKER},
  journal={Epidemiology and infection},
  volume={142 4},
  • F. Mooi, N. A. T. VAN DER MAAS, H. De MELKER
  • Published 2014
  • Medicine
  • Epidemiology and infection
  • Pertussis or whooping cough has persisted and resurged in the face of vaccination and has become one of the most prevalent vaccine-preventable diseases in Western countries. The high circulation rate of Bordetella pertussis poses a threat to infants that have not been (completely) vaccinated and for whom pertussis is a severe, life-threatening, disease. The increase in pertussis is mainly found in age groups in which immunity has waned and this has resulted in the perception that waning… CONTINUE READING

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    Publications referenced by this paper.
    Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen.
    • 191
    Improving pertussis vaccination
    • 67
    • Highly Influential
    Pertussis: a matter of immune modulation.
    • 89
    Small Mutations in Bordetella pertussis Are Associated with Selective Sweeps
    • 69
    • Highly Influential
    • PDF
    Factors contributing to pertussis resurgence.
    • 132
    Immunity to the respiratory pathogen Bordetella pertussis
    • 178
    • PDF
    A search for serologic correlates of immunity to Bordetella pertussis cough illnesses.
    • 394