Perturbed proteostasis in autism spectrum disorders


Dynamic changes in synaptic strength rely on de novo protein synthesis and protein degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular processes will result in significant impairments in synaptic plasticity and memory formation. Mutations in several genes encoding regulators of mRNA translation and members of the UPS… (More)
DOI: 10.1111/jnc.13723


4 Figures and Tables

Cite this paper

@inproceedings{Louros2016PerturbedPI, title={Perturbed proteostasis in autism spectrum disorders}, author={Susana R. Louros and Emily K Osterweil}, booktitle={Journal of neurochemistry}, year={2016} }