Perturbations in the Replication Program Contribute to Genomic Instability in Cancer


Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the… (More)
DOI: 10.3390/ijms18061138


4 Figures and Tables