Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus

@inproceedings{Wiemann2014PerturbationsIS,
  title={Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus},
  author={Philipp Wiemann and Beatrix Elisabeth Lechner and Joshua A Baccile and Thomas A. Velk and Wen-Bing Yin and Jin Woo Bok and Suman B. Pakala and Liliana Losada and William C. Nierman and Frank C Schroeder and Hubertus Haas and Nancy P Keller},
  booktitle={Front. Microbiol.},
  year={2014}
}
Iron plays a critical role in survival and virulence of the opportunistic pathogen Aspergillus fumigatus. Two transcription factors, the GATA-factor SreA and the bZip-factor HapX oppositely monitor iron homeostasis with HapX activating iron acquisition pathways (e.g., siderophores) and shutting down iron consumptive pathways (and SreA) during iron starvation conditions whereas SreA negatively regulates HapX and corresponding pathways during iron sufficiency. Recently the non-ribosomal peptide… CONTINUE READING
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Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology

Wiemann, Lechner, +9 authors Keller
2014

Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus

P Citation Wiemann, BE Lechner, +9 authors NP Keller
Front. Microbiol • 2014

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