Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa.

  title={Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa.},
  author={Pam R. Taub and Israel Ram{\'i}rez-S{\'a}nchez and Theodore P. Ciaraldi and Silvia Gonzalez-Basurto and Ram{\'o}n Mauricio Coral-V{\'a}zquez and Guy A Perkins and Michael C. Hogan and Alan S. Maisel and Robert R. Henry and Guillermo Ceballos and Francisco Villarreal},
  journal={Clinical science},
  volume={125 8},
HF (heart failure) and T2D (Type 2 diabetes) associate with detrimental alterations in SkM (skeletal muscle) structure/function. We have demonstrated recently that (-)-ERC (epicatechin-rich cocoa) improves SkM mitochondrial structure [Taub, Ramirez-Sanchez, Ciaraldi, Perkins, Murphy, Naviaux, Hogan, Ceballos, Maisel, Henry et al. (2012) Clin. Trans. Sci. 5, 43-47]. We hypothesized that an improved mitochondrial structure may facilitate the reversal of detrimental alterations in sarcomeric… 

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