Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis.

Abstract

The dynamic modification of nuclear and cytoplasmic proteins with O-linked beta-N-acetylglucosamine (O-GlcNAc) is a regulatory post-translational modification that is rapidly responsive to morphogens, hormones, nutrients, and cellular stress. Here we show that O-GlcNAc is an important regulator of the cell cycle. Increased O-GlcNAc (pharmacologically or… (More)

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Cite this paper

@article{Slawson2005PerturbationsIO, title={Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis.}, author={Chad Slawson and Natasha Elizabeth Zachara and Keith Vosseller and Win Den Cheung and Melissa D. Lane and Gerald W. Hart}, journal={The Journal of biological chemistry}, year={2005}, volume={280 38}, pages={32944-56} }