Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae.

@article{Howe2003PerturbationOT,
  title={Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae.},
  author={Kenneth James Howe and Caroline M. Kane and Manuel Ares},
  journal={RNA},
  year={2003},
  volume={9 8},
  pages={993-1006}
}
Unknown mechanisms exist to ensure that exons are not skipped during biogenesis of mRNA. Studies have connected transcription elongation with regulated alternative exon inclusion. To determine whether the relative rates of transcription elongation and spliceosome assembly might play a general role in enforcing constitutive exon inclusion, we measured exon skipping for a natural two-intron gene in which the internal exon is constitutively included in the mRNA. Mutations in this gene that subtly… CONTINUE READING
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