Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37.

@article{HenzlerWildman2004PerturbationOT,
  title={Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37.},
  author={Katherine A Henzler-Wildman and Gary V Martinez and Michael F Brown and A Ramamoorthy},
  journal={Biochemistry},
  year={2004},
  volume={43 26},
  pages={8459-69}
}
LL-37 is a cationic, amphipathic alpha-helical antimicrobial peptide found in humans that kills cells by disrupting the cell membrane. To disrupt membranes, antimicrobial peptides such as LL-37 must alter the hydrophobic core of the bilayer. Differential scanning calorimetry and deuterium ((2)H) NMR experiments on acyl chain perdeuterated lipids demonstrate that LL-37 inserts into the hydrophobic region of the bilayer and alters the chain packing and cooperativity. The results show that… CONTINUE READING
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Mechanism of Membrane Bilayer Disruption by the Human Antimicrobial Peptide, LL-37,Biochemistry

  • K. A. Henzler Wildman, D. K. Lee, A. Ramamoorthy
  • 2003
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