Perturbation of the T cell repertoire in rheumatoid arthritis.

  title={Perturbation of the T cell repertoire in rheumatoid arthritis.},
  author={Ulf G. Wagner and Kerstin Koetz and Cornelia M Weyand and J{\"o}rg J Goronzy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 24},
Aberrations in the T cell repertoire with the emergence of oligoclonal populations have been described in patients with rheumatoid arthritis (RA). However, the extent of the repertoire perturbations as well as the underlying mechanisms are not known. We now have examined the diversity of the peripheral CD4 T cell repertoire by determining the frequencies of… CONTINUE READING