Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells.

@article{Ward2003PerturbationOH,
  title={Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells.},
  author={Jeanine A Ward and Lei Huang and Huiming Guo and Shilenath Ghatak and Bryan P. Toole},
  journal={The American journal of pathology},
  year={2003},
  volume={162 5},
  pages={1403-9}
}
Malignant progression of gliomas is characterized by acquisition of inappropriate growth and invasive properties. In vitro, these malignant properties are reflected in, and measured by, the ability to grow in an anchorage-independent manner and to invade artificial extracellular matrices. The results of numerous studies have suggested that the extracellular and pericellular matrix polysaccharide, hyaluronan, plays an important role in these attributes of malignant cancer cells. However, with… CONTINUE READING