Perturbation of cytochrome P450, generation of oxidative stress and induction of DNA damage in Cyprinus carpio exposed in situ to potable surface water.

@article{Sapone2007PerturbationOC,
  title={Perturbation of cytochrome P450, generation of oxidative stress and induction of DNA damage in Cyprinus carpio exposed in situ to potable surface water.},
  author={Andrea Sapone and Bianca Gustavino and Monica Monfrinotti and Donatella Canistro and Massimiliano Broccoli and Laura Pozzetti and Alessandra Affatato and Luca Valgimigli and Giorgio Cantelli Forti and Gian Franco Pedulli and Gian Luigi Biagi and S. Z. Abdel-Rahman and M. Paolini},
  journal={Mutation research},
  year={2007},
  volume={626 1-2},
  pages={143-54}
}
Epidemiological evidence suggests a link between consumption of chlorinated drinking water and various cancers. Chlorination of water rich in organic chemicals produces carcinogenic organochlorine by-products (OBPs) such as trihalomethanes and haloacetic acids. Since the discovery of the first OBP in the 1970s, there have been several investigations designed to determine the biological effects of single chemicals or small artificial OBP combinations. However, there is still insufficient… CONTINUE READING
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