Perturbation of cranial neural crest migration by the HNK-1 antibody.

  title={Perturbation of cranial neural crest migration by the HNK-1 antibody.},
  author={Marianne Bronner-Fraser},
  journal={Developmental biology},
  volume={123 2},
The HNK-1 antibody recognizes a carbohydrate moiety that is shared by a family of cell adhesion molecules and is also present on the surface of migrating neural crest cells. Here, the effects of the HNK-1 antibody on neural crest cells were examined in vitro and in vivo. When the HNK-1 antibody was added to neural tube explants in tissue culture, neural crest cells detached from laminin substrates but were unaffected on fibronectin substrates. In order to examine the effects of the HNK-1… CONTINUE READING


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