Perturbation of cellular calcium induces secretion of luminal ER proteins.

@article{Booth1989PerturbationOC,
  title={Perturbation of cellular calcium induces secretion of luminal ER proteins.},
  author={Christopher R. Booth and Gordon L. E. Koch},
  journal={Cell},
  year={1989},
  volume={59 4},
  pages={729-37}
}
The endoplasmic reticulum (ER) contains a family of luminal proteins (reticuloplasmins) that are normally excluded from the secretory pathway. However, reticuloplasmins are efficiently secreted when murine fibroblasts are treated with calcium ionophores. The secreted and cellular forms of endoplasmin are clearly distinguishable on the basis of gel mobility and endoglycosidase H sensitivity. Reticuloplasmin secretion leads to the depletion of the proteins from the ER and their accumulation in… CONTINUE READING
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