Perturbation of cell cycle regulators in human cancer.

  title={Perturbation of cell cycle regulators in human cancer.},
  author={Ignacio Palmero and Gordon G Peters},
  journal={Cancer surveys},
Progression through the mammalian cell cycle requires the sequential activation of a series of cyclin dependent kinases. The activity of these kinases is regulated at several levels and the current challenge is to determine how the various signal transduction pathways are linked to the cell cycle machinery. An obvious focus is the so-called restriction point in late G1, and current evidence suggests that this is in part determined by the phosphorylation of the retinoblastoma protein (Rb) by the… CONTINUE READING

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