Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma.

  title={Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma.},
  author={Venugopal Thayanithy and Aaron L. Sarver and Reena V. Kartha and Lihua Li and Andrea Y Angstadt and Matthew Breen and Clifford J. Steer and Jaime F Modiano and Subbaya Subramanian},
  volume={50 1},
Osteosarcoma (OS) is the common histological form of primary bone cancer and one of the leading aggressive cancers in children under age fifteen. Although several genetic predisposing conditions have been associated with OS the understanding of its molecular etiology is limited. Here, we show that microRNAs (miRNAs) at the chr.14q32 locus are significantly downregulated in osteosarcoma compared to normal bone tissues. Bioinformatic predictions identified that a subset of 14q32 miRNAs (miR-382… CONTINUE READING