Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model.

@article{Safarchi2015PertactinNB,
  title={Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model.},
  author={Azadeh Safarchi and Sophie Octavia and Laurence Don Wai Luu and Chin Yen Alfred Tay and Vitali Sintchenko and Nicholas James Wood and Helen Siobhan Marshall and Peter Bruce McIntyre and Ruiting Lan},
  journal={Vaccine},
  year={2015},
  volume={33 46},
  pages={6277-81}
}
Whooping cough or pertussis is a highly infectious respiratory disease in humans caused by Bordetella pertussis. The use of acellular vaccines (ACV) has been associated with the recent resurgence of pertussis in developed countries including Australia despite high vaccination coverage where B. pertussis strains that do not express pertactin (Prn), a key antigenic component of the ACV, have emerged and become prevalent. In this study, we used an in vivo competition assay in mice immunised with… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…