Perspectives on tubulin isotype function and evolution based on the observation that Tetrahymena thermophila microtubules contain a single alpha- and beta-tubulin.

@article{Gaertig1993PerspectivesOT,
  title={Perspectives on tubulin isotype function and evolution based on the observation that Tetrahymena thermophila microtubules contain a single alpha- and beta-tubulin.},
  author={Jacek Gaertig and Thomas H Thatcher and Kathleen E. McGrath and R C Callahan and M. A. Gorovsky},
  journal={Cell motility and the cytoskeleton},
  year={1993},
  volume={25 3},
  pages={243-53}
}
We have cloned and sequenced the two beta-tubulin genes of the ciliated protozoan Tetrahymena thermophila. The two genes encode identical 443 amino acid peptides which are 99.7% identical to the beta-tubulin proteins of T. pyriformis and 95% identical to human beta 1 tubulin. T. thermophila contains only one alpha-tubulin gene (Callahan et al., 1984: Cell 36:441-445). Thus, all of the extremely diverse microtubule structures in this unicellular organism can be formed from a single alpha- and a… CONTINUE READING

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