Perspectives on genetic animal models of serotonin toxicity

  title={Perspectives on genetic animal models of serotonin toxicity},
  author={Allan Kalueff and Justin L. Laporte and Dennis L. Murphy},
  journal={Neurochemistry International},
Serotonin syndrome, or serotonin toxicity, is a serious disorder attributable to exaggerated serotonergic function in the brain, most commonly after antidepressant overdose or after combining several psychotropic medications. Similar condition (serotonin syndrome-like behavior) can be evoked in animals experimentally, following administration of serotonergic drugs. In addition to pharmacological stimulation, some genetic and other factors may contribute to serotonin toxicity, prompting the need… CONTINUE READING

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