Perspectives on clinical and preclinical testing of new tuberculosis vaccines.

  title={Perspectives on clinical and preclinical testing of new tuberculosis vaccines.},
  author={Arthur M. Dannenberg},
  journal={Clinical microbiology reviews},
  volume={23 4},
This review hopes to improve the selection of new tuberculosis (TB) vaccines by providing several perspectives on the immunization of humans, mice, guinea pigs, rabbits, and monkeys which have not usually been considered. (i) In human TB vaccine trials, the low rate of healing of Mycobacterium bovis BCG lesions (used as the control group) would distinguish individuals who might be helped by vaccination from the 95% who do not need it and would make these trials more conclusive. (ii) The rabbit… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 102 references

Tuberculosis in animals and man: a study in comparative pathology

  • J. Francis
  • 1958
Highly Influential
4 Excerpts

Pathogenesis of human tuberculosis: insights from the rabbit model

  • A. M. Dannenberg, Jr.
  • 2006
Highly Influential
10 Excerpts

BCG vaccines and vaccination, p. 503–522

  • P.E.M. Fine
  • 2000
Highly Influential
4 Excerpts

Clinical and Preclinical Testing of New Tb Vaccines

  • E. Ribi, R. L. Anacker, W. R. Barclay, W. Brehmer, S. C. Harris, W. R. Leif
  • rasm .rg/ D ow nladed fom and J. Simmons
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…