Perspectives on clinical and preclinical testing of new tuberculosis vaccines.

@article{Dannenberg2010PerspectivesOC,
  title={Perspectives on clinical and preclinical testing of new tuberculosis vaccines.},
  author={Arthur M. Dannenberg},
  journal={Clinical microbiology reviews},
  year={2010},
  volume={23 4},
  pages={781-94}
}
This review hopes to improve the selection of new tuberculosis (TB) vaccines by providing several perspectives on the immunization of humans, mice, guinea pigs, rabbits, and monkeys which have not usually been considered. (i) In human TB vaccine trials, the low rate of healing of Mycobacterium bovis BCG lesions (used as the control group) would distinguish individuals who might be helped by vaccination from the 95% who do not need it and would make these trials more conclusive. (ii) The rabbit… CONTINUE READING

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