Perspectives on UV light mutagenesis: investigation of the CHO aprt gene carried on a retroviral shuttle vector.

Abstract

The extent to which the cellular processing of shuttle vector-carried genes reflects that of endogenous chromosomal loci has been a subject of considerable controversy. In order to address this issue, we have developed a retroviral-based shuttle vector carrying the Chinese hamster ovary (CHO) adenine phosphoribosyltransferase (aprt) gene stably integrated… (More)

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