Perspectives of biotechnological production of l-tyrosine and its applications

  title={Perspectives of biotechnological production of l-tyrosine and its applications},
  author={Tina L{\"u}tke-Eversloh and Christine Nicole S. Santos and Gregory Stephanopoulos},
  journal={Applied Microbiology and Biotechnology},
The aromatic amino acid l-tyrosine is used as a dietary supplement and has promise as a valuable precursor compound for various industrial and pharmaceutical applications. In contrast to chemical production, biotechnological methods can produce l-tyrosine from biomass feedstocks under environmentally friendly and near carbon-free conditions. In this minireview, various strategies for synthesizing l-tyrosine by employing biocatalysts are discussed, including initial approaches as well as more… 
Recent advances in biocatalytic derivatization of L-tyrosine.
This review summarizes typical L-tyrosine derivatizations catalyzed by enzymatic biocatalysts, as well as the strategies and challenges associated with their production processes, and discusses future perspectives pertaining to the enzymatics production of L-Tyrosine derivatives.
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Precise tuning of the glyoxylate cycle in Escherichia coli for efficient tyrosine production from acetate
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For almost 50 years now, biotechnological production processes have been used for industrial production of amino acids, and the use of enzymes and whole cell biocatalysts has proven particularly valuable in production of both proteinogenic and nonproteinogenic l-amino acids.
Towards bacterial strains overproducing l-tryptophan and other aromatics by metabolic engineering
  • M. Ikeda
  • Biology, Engineering
    Applied Microbiology and Biotechnology
  • 2006
In this review, advances in metabolic engineering for the production of the aromatic amino acids and useful aromatic intermediates are described with particular emphasis on two representative producer organisms, Corynebacterium glutamicum and Escherichia coli.
Development of a combined biological and chemical process for production of industrial aromatics from renewable resources.
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    Annual review of microbiology
  • 2007
The multifaceted approach, which integrates biology, chemistry, and engineering, has allowed development of an economical process at scales suitable for industrial applications.
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Fed-batch fermentations revealed that l-tyrosine production was tightly correlated with cell growth, exhibiting the maximum productivity at the end of the exponential growth phase.
Metabolic engineering for microbial production of shikimic acid.
Biocatalytic syntheses of aromatics from D-glucose: renewable microbial sources of aromatic compounds.
This review describes ways of achieving the traditional strategy of manipulating the catalytic activity of the first enzyme in the common pathway, as well as the amelioration of limitations in the in vivo availability of common-pathway enzyme substrates.
Development of bioreactor system for L-tyrosine synthesis using thermostable tyrosine phenol-lyase.
An efficient enzyme system for the synthesis of L-tyrosine was developed using a fed-batch reactor with continuous feeding of phenol, pyruvate, and ammonia. A thermo- and chemostable tyrosine
Distribution of Tyrosine Phenol Lyase in Microorganisms
Results of the isolation and identification of the products showed that the amino acid synthesized by this enzymatic method was identical with l-tyrosine or l-dopa.