Perspectives of antimony compounds in oncology

@article{Sharma2008PerspectivesOA,
  title={Perspectives of antimony compounds in oncology},
  author={Pankaj Kumar Sharma and Diego P{\'e}rez and Armando Cabrera and Noe Rosas and Jose Luis Arias},
  journal={Acta Pharmacologica Sinica},
  year={2008},
  volume={29},
  pages={881-890}
}
AbstractAntimony, a natural element that has been used as a drug for over more than 100 years, has remarkable therapeutic efficacy in patients with acute promyelocytic leukemia. This review focuses on recent advances in developing antimony anticancer agents with an emphasis on antimony coordination complexes, Sb (III) and Sb (V). These complexes, which include many organometallic complexes, may provide a broader spectrum of antitumoral activity. They were compared with classical platinum… Expand
Recent advances on antimony(III/V) compounds with potential activity against tumor cells.
TLDR
This survey shows that antimony(III/V) complexes containing various types of ligands such as thiones, thiosemicarbazones, dithiocarbamates, carboxylic acids, or ketones, nitrogen donor ligands, exhibit selectivity against a variety of cancer cells. Expand
Anticancer Activity of Molecular Compounds of Arsenic, Antimony and Bismuth
Metal based drugs continue to play a vital role in contemporary medicine. Accordingly, molecular complexes of platinum(II) for example, cisplatin (I) and carboplatin (II), find wide use asExpand
Metals in Oncology: An Overview
This paper is an attempt to survey the literature of metal in oncology and also to give relative insight of effectiveness of different metals and their compounds against tumors cell lines. In thisExpand
Non steroidal anti-inflammatory drug (NSAIDs) in breast cancer chemotherapy; antimony(V) salicylate a DNA binder
Abstract The organoantimony(V) derivative of salicylic acid (SalH2), {[Ph3Sb(SalH)]2O} (SalOSbi) was synthesized and tested for its anti-proliferative activity. SalOSbi was characterized by meltingExpand
Metalloid compounds as drugs
  • B. S. Sekhon
  • Medicine, Chemistry
  • Research in pharmaceutical sciences
  • 2013
TLDR
The six elements commonly known as metalloids are boron, silicon, germanium, arsenic, antimony, and tellurium, which have been used as antiprotozoal drugs and organosilicon compounds have been shown to be effective in vitro multidrug-resistance reverting agents. Expand
Antimony enhances c-Myc stability in prostate cancer via activating CtBP2-ROCK1 signaling pathway.
TLDR
This study demonstrated that antimony could enhance c-Myc protein stability and promote prostate cancer cell proliferation through activating CtBP2-ROCK1 signaling pathway and substantially highlighted the potential of targeting molecules within antimony induced Ct BP2-c- myc signaling pathway as a promising therapeutic approach for the treatment of prostate cancer. Expand
Effect of cobalt(II) chloride hexahydrate on some human cancer cell lines
TLDR
Interestingly, it was found that CoCl2·6H2O induces more cell death in cancerous cells as compared to normal non-cancerous cells, and was presented as potential antiproliferative agent. Expand
Small molecule inhibitors of DNA repair nuclease activities of APE1
TLDR
This review summarizes the current state of the efforts to design potent and selective inhibitors against APE1 AP site incision activity and envisioned that such inhibitors will be used in combinatorial treatment paradigms to enhance the efficacy of DNA-interactive drugs that introduce relevant cytotoxic DNA lesions. Expand
Toxicometallomics for research on the toxicology of exotic metalloids based on speciation studies.
  • Y. Ogra
  • Chemistry, Medicine
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • 2009
TLDR
The role of speciation in considering the metabolism of tellurium and antimony from the viewpoint of toxicometallomics is described and oxidation in human and rat and methylation also occurs as a minor metabolic pathway in humans are described. Expand
DFT-based prediction of antifungal and insecticidal activities of perfluorophenyl antimony(III) and antimony(V) chlorides
Abstract Perfluorophenyl antimony(III) and antimony(V) chlorides experimentally scanned earlier for antifungal activity against Aspergillus flavus and Aspergillus niger, and insecticidal activityExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 106 REFERENCES
Antimony and bismuth compounds in oncology.
  • E. Tiekink
  • Medicine
  • Critical reviews in oncology/hematology
  • 2002
TLDR
The main group elements antimony and bismuth are used clinically, primarily for the treatment of Leishmaniasis and ulcers, and promising anti-tumour activity has been reported, in particular for bismUTH compounds. Expand
Metals and metal compounds in cancer treatment.
  • B. Desoize
  • Medicine, Biology
  • Anticancer research
  • 2004
TLDR
This review has summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. Expand
Resistance to Arsenic- and Antimony-Based Drugs
TLDR
Arsenic trioxide, As203, has been used for a long time in traditional Chinese medicines for treatment of various diseases, and it has recently been shown to be clinically active in acute promyelocytic leukemias. Expand
Chemical and biotechnological developments in organotin cancer chemotherapy
This review provides a substantial knowledge on the action mode of organotins in cancer chemotherapy. The coordinating ability of organotin compounds towards DNA and cancer cells is discussed. MostExpand
Chemotherapy for leishmaniasis: biochemical mechanisms, clinical efficacy, and future strategies.
  • J. Berman
  • Biology, Medicine
  • Reviews of infectious diseases
  • 1988
TLDR
Preliminary clinical studies suggest that the purines and the sterol inhibitors may have clinical utility as oral agents against cutaneous leishmaniasis. Expand
Complexes of metals other than platinum as antitumour agents
  • P. Köpf-Maier
  • Chemistry, Medicine
  • European Journal of Clinical Pharmacology
  • 2004
TLDR
Several platinum complexes and four non-platinum-metal antitumour agents have so far entered early clinical trials, and Gallium trinitrate and spirogermanium have shown limited cytostatic activity against certain human carcinomas and lymphomas. Expand
Biological activities and antitumor mechanism of an immunopotentiating organogermanium compound, Ge-132 (review).
TLDR
The biological activities and antitumor mechanism of an immunopotentiator, Ge-132, is reviewed herein and it was shown that T-cells and macrophages were involved when tumor-bearing mice were protected by the compound. Expand
Cytotoxic and Antitumor Activity of Antimony(III) Nitrilotriacetate Complexes M2SB(Nta)(HNta) · nH2O (M = NH4, Na; n = 1, 2)
Antimony(III) nitrilotriacetate complexes with mixed Nta3− and HNta2− ligands of composition (NH4)2Sb(Nta)(HNta) · nH2O (I) and Na2Sb(Nta)(HNta) · 2H2O (II) were synthesized. The proposed structuresExpand
Antimony(V) complex formation with adenine nucleosides in aqueous solution.
TLDR
The data suggests that the formation of such complexes may take place in vivo within the acidic cell compartments, including the phagolysosome of macrophage in which Leishmania resides. Expand
Anticancer Activity of Sodium Stibogluconate in Synergy with IFNs1
TLDR
SSG enhanced IFN-α-induced Stat1 tyrosine phosphorylation, inactivated intracellular SHP-1 andSHP-2 that negatively regulate IFN signaling, and induced cellular protein tyrosines phosphorylated in cancer cell lines, which are consistent with inactivation of phosphatases as the basis of SSG anticancer activity. Expand
...
1
2
3
4
5
...