Perspectives in mammalian IGFBP-3 biology: local vs. systemic action.
@article{Yamada2009PerspectivesIM, title={Perspectives in mammalian IGFBP-3 biology: local vs. systemic action.}, author={Paulette M. Yamada and Kuk-Wha Lee}, journal={American journal of physiology. Cell physiology}, year={2009}, volume={296 5}, pages={ C954-76 } }
Insulin-like growth factor (IGF) binding protein (IGFBP)-3 has traditionally been defined by its role as a binding protein and its association with IGF delivery and availability. Development of non-IGF binding IGFBP-3 analogs and the use of cell lines devoid of type 1 IGF receptors (IGF-R) have led to critical advances in the field of IGFBP-3 biology. These studies show that IGFBP-3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor…
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