Perspectives in mammalian IGFBP-3 biology: local vs. systemic action.

  title={Perspectives in mammalian IGFBP-3 biology: local vs. systemic action.},
  author={Paulette M. Yamada and Kuk-Wha Lee},
  journal={American journal of physiology. Cell physiology},
  volume={296 5},
  • P. Yamada, Kuk-Wha Lee
  • Published 1 May 2009
  • Biology, Medicine
  • American journal of physiology. Cell physiology
Insulin-like growth factor (IGF) binding protein (IGFBP)-3 has traditionally been defined by its role as a binding protein and its association with IGF delivery and availability. Development of non-IGF binding IGFBP-3 analogs and the use of cell lines devoid of type 1 IGF receptors (IGF-R) have led to critical advances in the field of IGFBP-3 biology. These studies show that IGFBP-3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor… 

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