Perspectives in alkaline phosphatase research.

  title={Perspectives in alkaline phosphatase research.},
  author={D. W. Moss},
  journal={Clinical chemistry},
  volume={38 12},
Gene cloning and site-directed mutagenesis have had a profound effect on alkaline phosphatase research. Four distinct structural genes encoding placental, intestinal, and tissue-nonspecific isoenzymes have been cloned, sequenced, and mapped to human chromosomes. Differences in properties between the respective gene products are due to variations in primary structure involving only one, or a few, key amino acid residues. Recognition that alkaline phosphatase belongs to the category of molecules… CONTINUE READING