Perspectives in Pharmacology Translation of Central Nervous System Occupancy from Animal Models : Application of Pharmacokinetic / Pharmacodynamic Modeling

Abstract

Translation of central nervous system receptor occupancy from animal models to humans has been elusive for many therapeutic targets. However, this may represent a valuable link to clinical efficacy for drugs acting within the brain and spinal cord. The introduction of positron emission tomography marked a significant noninvasive advance in determination of… (More)

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