Perspectives in Pharmacology Structure-Functional Diversity of Human L-Type Ca Channel: Perspectives for New Pharmacological Targets


The L-type Ca channels mediate depolarization-induced influx of Ca into a wide variety of cells and thus play a central role in triggering cardiac and smooth muscle contraction. Because of this role, clinically important classes of 1,4-dihydropyridine, phenylalkylamine, and benzothiazepine Ca channel blockers were developed as powerful medicines to treat… (More)


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