Perspectives in Endocrine Toxicity of Heavy Metals—A Review

  title={Perspectives in Endocrine Toxicity of Heavy Metals—A Review},
  author={Suresh Vir Singh Rana},
  journal={Biological Trace Element Research},
  • S. Rana
  • Published 6 June 2014
  • Medicine, Biology
  • Biological Trace Element Research
An attempt has been made to review the endocrine/hormonal implications of a few environmentally significant metals, viz, lead, mercury, cadmium, copper, arsenic and nickel, in man and animals. Special emphasis has been given to the adrenals, thyroid, testis, ovary and pancreas. Toxic metals can cause structural and functional changes in the adrenal glands. Their effects on steroidogenesis have been reviewed. It has been reported that thyroid hormone kinetics are affected by a number of metallic… 
Overview of Cadmium Thyroid Disrupting Effects and Mechanisms
In vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships, and further studies needed to elucidate the issue and improve the understanding of Cd-mediated effects on the thyroid gland.
Which Strategies can be Adopted against Heavy Metal Intoxication
Essential metals, vitamins, edible plants, phytochemicals, and probiotics have been proposed, in association with a selection of recommended food products, and various pharmacologic targets of inflammation have been considered.
Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review
In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated and biomarkers based on trace metal ratios are proposed.
Nutraceuticals: A New Challenge against Cadmium-Induced Testicular Injury
Dietary strategies and the use of nutraceuticals, particularly abundant in fresh fruits, beans, vegetables and grains, typical of the Mediterranean diet, are recommended against Cd-induced testicular injury.
Heavy Metal Toxicity
Symptoms and signs of heavy metal(HM) toxicity vary with the substance and can be due to acute exposure to large amounts, or chronic exposure to repeated small quantities which can result in cumulative toxicity.
Heavy metals in the volcanic environment and thyroid cancer


New aspects of cadmium as endocrine disruptor.
  • M. Takiguchi, S. Yoshihara
  • Biology, Medicine
    Environmental sciences : an international journal of environmental physiology and toxicology
  • 2006
Evidence thus far presented concerning the effects of Cd on the endocrine system is discussed and it is shown that Cd has potent estrogen- and androgens-like activities in vivo and in vitro, by directly binding to estrogen and androgen receptors.
Cadmium-induced testicular injury.
Cadmium: toxic effects on the reproductive system and the embryo.
[Effects of cadmium on testis function].
Increasing environmental exposure to cadmium, currently existing occupational exposure and the prevalence of tobacco smoking results in constant increase in the number of diagnosed fertility impairments.
Toxic effect of heavy metals on cells isolated from the rat adrenal and testis
  • T. Ng, W. Liu
  • Biology, Medicine
    In Vitro Cellular & Developmental Biology
  • 2007
Mercury, cadmium, cobalt, and copper exerted an adverse effect on the viability of isolated rat adrenal capsular, adrenal decapsular, and Leydig cells of the testis with mercury being the most potent.
Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin
The results strongly suggest that cadmium may cause a decline in placental leptin synthesis, as it has been shown for placental progesterone production, and may constitute further evidence of the endocrine‐disrupting effects of Cadmium, as a constituent of tobacco smoke, on reproduction in women.
Heavy metals, islet function and diabetes development
The evidence which suggests that some heavy metals may play an important role in diabetes mellitus as environmental risk factors is summarized.
Role of oxidative stress in cadmium toxicity and carcinogenesis.
The effect of lead intoxication on endocrine functions
Findings suggest that lead initially causes some subclinical testicular damage, followed by hypothalamic or pituitary disturbance when longer periods of exposure take place, and lead toxicity involves alterations on calcitropic hormones’ homeostasis, which increase the risk of skeletal disorders.