Perspectives in Endocrine Toxicity of Heavy Metals—A Review

@article{Rana2014PerspectivesIE,
  title={Perspectives in Endocrine Toxicity of Heavy Metals—A Review},
  author={Suresh Vir Singh Rana},
  journal={Biological Trace Element Research},
  year={2014},
  volume={160},
  pages={1-14}
}
  • S. Rana
  • Published 6 June 2014
  • Medicine, Biology
  • Biological Trace Element Research
An attempt has been made to review the endocrine/hormonal implications of a few environmentally significant metals, viz, lead, mercury, cadmium, copper, arsenic and nickel, in man and animals. Special emphasis has been given to the adrenals, thyroid, testis, ovary and pancreas. Toxic metals can cause structural and functional changes in the adrenal glands. Their effects on steroidogenesis have been reviewed. It has been reported that thyroid hormone kinetics are affected by a number of metallic… 
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References

SHOWING 1-10 OF 158 REFERENCES
New aspects of cadmium as endocrine disruptor.
  • M. Takiguchi, S. Yoshihara
  • Biology, Medicine
    Environmental sciences : an international journal of environmental physiology and toxicology
  • 2006
TLDR
Evidence thus far presented concerning the effects of Cd on the endocrine system is discussed and it is shown that Cd has potent estrogen- and androgens-like activities in vivo and in vitro, by directly binding to estrogen and androgen receptors.
Cadmium-induced testicular injury.
Cadmium: toxic effects on the reproductive system and the embryo.
Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review).
[Effects of cadmium on testis function].
TLDR
Increasing environmental exposure to cadmium, currently existing occupational exposure and the prevalence of tobacco smoking results in constant increase in the number of diagnosed fertility impairments.
Toxic effect of heavy metals on cells isolated from the rat adrenal and testis
  • T. Ng, W. Liu
  • Biology, Medicine
    In Vitro Cellular & Developmental Biology
  • 2007
TLDR
Mercury, cadmium, cobalt, and copper exerted an adverse effect on the viability of isolated rat adrenal capsular, adrenal decapsular, and Leydig cells of the testis with mercury being the most potent.
Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin
TLDR
The results strongly suggest that cadmium may cause a decline in placental leptin synthesis, as it has been shown for placental progesterone production, and may constitute further evidence of the endocrine‐disrupting effects of Cadmium, as a constituent of tobacco smoke, on reproduction in women.
Heavy metals, islet function and diabetes development
TLDR
The evidence which suggests that some heavy metals may play an important role in diabetes mellitus as environmental risk factors is summarized.
Role of oxidative stress in cadmium toxicity and carcinogenesis.
The effect of lead intoxication on endocrine functions
TLDR
Findings suggest that lead initially causes some subclinical testicular damage, followed by hypothalamic or pituitary disturbance when longer periods of exposure take place, and lead toxicity involves alterations on calcitropic hormones’ homeostasis, which increase the risk of skeletal disorders.
...
...