Perspectives in Drug Development and Clinical Pharmacology: The Discovery of Histamine H1 and H2 Antagonists

@article{Jones2016PerspectivesID,
  title={Perspectives in Drug Development and Clinical Pharmacology: The Discovery of Histamine H1 and H2 Antagonists},
  author={Alan Wayne Jones},
  journal={Clinical Pharmacology in Drug Development},
  year={2016},
  volume={5}
}
  • A. Jones
  • Published 2016
  • Biology
  • Clinical Pharmacology in Drug Development
Knowledge about the history and development of therapeutic agents holds a central position in the education and training of pharmacists and pharmacologists. Students enjoy learning about the discovery of drugs, including details about the pioneer workers involved (apothecaries, organic chemists, pharmacologists, and physiologists) and the role played by serendipity. The treatment of people suffering from allergies and the development of drugs that block the actions of histamine at H1 and H2… 
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10 Citations
Highly Influential Citations
1
Background Citations
5

10 Citations

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Proton pump inhibitors (PPIs) have become some of the most frequently prescribed medications in both children and adults, and their effectiveness for treatment of peptic conditions in the pediatric population has been established.
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Investigating G protein-coupled receptor 35 signalling and its role in cardiovascular disease
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A pathological role for GPR35 is demonstrated in the development of hypertension and its associated end-organ damage in the stroke-prone spontaneously hypertensive rat, and studies suggest that antagonism of G PR35 could be a novel therapeutic strategy to treat hypertension and/or heart failure.
Effects of Histidine and &bgr;-alanine Supplementation on Human Muscle Carnosine Storage
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It is confirmed that &bgr;-alanine, and not L-histidine, is the rate-limiting precursor for carnosine synthesis in human skeletal muscle.
The Effects of Acute and Chronic Diphenhydramine and Cetirizine Use on Learning and Memory in Rats
Hacettepe Universitesi Bilimsel Arastirma Projeleri Koordinasyon Birimi, Proje Numarasi: THD-2017-16553
Acid Suppressive Therapy
Pharmacological Management of Allergic Rhinitis in the Elderly
TLDR
The main management trend for allergic rhinitis in elderly patients is the same as the trend in young patients, and Pharmacological treatment is quite similar in both older and younger patients with allergic Rhinitis.

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