Perspectives in Diabetes What P-cell Defect Could Lead to Hyperproinsulinemia in NIDDM ? Some Clues From Recent Advances Made in Understanding the Proinsulin-Processing Mechanism


Pancreatic @-cell dysfunction is a characteristic of noninsulin-dependent diabetes mellitus (NIDDM). An aspect of this dysfunction is that an increased proportion of proinsulin is secreted, but an actual P-cell defect that leads to hyperproinsulinemia is unknown. Nevertheless, an impairment in P-cell proinsulin conversion mechanism has been suggested as the… (More)


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