Perspectives: using polymer modeling to understand the formation and function of nuclear compartments

@inproceedings{Haddad2016PerspectivesUP,
  title={Perspectives: using polymer modeling to understand the formation and function of nuclear compartments},
  author={Noelle Haddad and Daniel Jost and C{\'e}dric Vaillant},
  booktitle={Chromosome Research},
  year={2016}
}
Compartmentalization is a ubiquitous feature of cellular function. In the nucleus, early observations revealed a non-random spatial organization of the genome with a large-scale segregation between transcriptionally active—euchromatin—and silenced—heterochromatin—parts of the genome. Recent advances in genome-wide mapping and imaging techniques have strikingly improved the resolution at which nuclear genome folding can be analyzed and have revealed a multiscale spatial compartmentalization with… CONTINUE READING
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