Perspective p 16 INK 4 a as a Second Effector of the Telomere Damage Pathway

@inproceedings{Jacobs2006PerspectiveP1,
  title={Perspective p 16 INK 4 a as a Second Effector of the Telomere Damage Pathway},
  author={Jacqueline J L Jacobs and Titia de Lange},
  year={2006}
}
Telomere damage resulting from telomere shortening can potentially suppress tumorigenesis by permanently arresting or eliminating incipient cancer cells. Dysfunctional telomeres activate the canonical DNA damage response pathway, resulting in a p53mediated G1/S arrest and senescence or apoptosis. Experimental induction of telomere damage through inhibition of the telomeric protein TRF2 recapitulates aspects of telomere attrition, including a p53-mediated cell cycle arrest. Using this system, we… CONTINUE READING
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