Perspective on mutagenesis and repair: the standard model and alternate modes of mutagenesis.

@article{Miller2005PerspectiveOM,
  title={Perspective on mutagenesis and repair: the standard model and alternate modes of mutagenesis.},
  author={J. H. Miller},
  journal={Critical reviews in biochemistry and molecular biology},
  year={2005},
  volume={40 3},
  pages={
          155-79
        }
}
The basic ideas of replication, mutagenesis, and repair have outlined a picture of how point mutations occur that has provided a valuable framework for theory and experiment, much as the Standard Model of particle physics has done for our concept of fundamental particles. However, alternative modes of mutagenesis are being defined that are changing our perspective of the "Standard Model" of mutagenesis, requiring an expanded model. The genome is now envisioned as being in dynamic equilibrium… CONTINUE READING
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