Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases.

@article{Rao2014PerspectiveAP,
  title={Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases.},
  author={Shasha Rao and Angel Tan and Nicky Thomas and Clive A Prestidge},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={193},
  pages={174-87}
}
Cardiovascular diseases (CVDs) remain the major cause of morbidity and mortality globally. Despite the large number of cardiovascular drugs available for pharmacological therapies, factors limiting the efficient oral use are identified, including low water solubility, pre-systemic metabolism, food intake effects and short half-life. Numerous in vivo proof-of-concepts studies are presented to highlight the viability of lipid-based delivery to optimize the oral delivery of cardiovascular drugs… CONTINUE READING
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