Perspective: purging the genetic load: a review of the experimental evidence.

@article{Crnokrak2002PerspectivePT,
  title={Perspective: purging the genetic load: a review of the experimental evidence.},
  author={Peter Crnokrak and Spencer C H Barrett},
  journal={Evolution; international journal of organic evolution},
  year={2002},
  volume={56 12},
  pages={2347-58}
}
Inbreeding depression, the reduction in fitness that accompanies inbreeding, is one of the most important topics of research in evolutionary and conservation genetics. In the recent literature, much attention has been paid to the possibility of purging the genetic load. If inbreeding depression is due to deleterious alleles, whose effect on fitness are negative when in a homozygous state, then successive generations of inbreeding may result in a rebound in fitness due to the selective decrease… CONTINUE READING