Perspective: Molecular Identity of the Outwardly Rectifying, Swelling-activated Anion Channel: Time to Reevaluate pICln

  title={Perspective: Molecular Identity of the Outwardly Rectifying, Swelling-activated Anion Channel: Time to Reevaluate pICln },
  author={Karen L. Strange},
  journal={The Journal of General Physiology},
  pages={617 - 622}
Cells respond to swelling by activating anion and cation channels that allow the passive loss of inorganic ions and organic solutes. Net solute efflux accompanied by osmotically obliged water functions to return cell volume towards its original value, a process termed regulatory volume decrease. An apparently ubiquitous response to swelling in vertebrate cells is activation of an outwardly rectifying an-ion current termed I Cl.swell. The general characteristics of this current include an… CONTINUE READING


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Publications referenced by this paper.

Molecular characterization of a swelling - induced chloride conductance regulatory protein , pICln

  • M. J. Ackerman, E. A. Gordon, L. D. Krapivinsky, D. E. Clapham
  • Cell .
  • 1994
Highly Influential
4 Excerpts

Activation of volume - regulated anion current ( VRAC ) is dependent on I Cln expression

  • P. S. Jackson, K. Churchwell, N. Ballatori, J. L. Boyer, K. Strange
  • Biophys . J .
  • 1998

GXGXG motif in the pICln protein is not important for the nucleotide sensitivity of the pICln - induced Cl 2 current in Xenopus oocytes

  • T. Voets, G. Buyse, J. Tytgat, G. Droogmans, J. Eggermont, B. Nilius
  • FEBS Lett
  • 1998
1 Excerpt

Reconstitution of recombinant pICln in planar lipid bilayers

  • L. Lorenz, M. Pusch
  • 1998

Regulation of the volume sensitivity of the I Cl . swell channel : ATP dependence is modulated by the rate of cell swelling

  • G. Buyse, T. Voets, J. Tytgat, C. De Greef, G. Droogmans, B. Nilius
  • FASEB J .
  • 1998

Expression of human pICln and ClC - 6 in Xenopus oocytes induces an identical endogenous chloride conductance

  • P. Thorn
  • J . Biol . Chem .
  • 1997

Hypotonic exposure stimulates translocation of the swelling - activated channel protein pI Cln in neonatal rat myocytes

  • S. Grunder, A. Thiemann, M. Pusch, T. J. Jentsch
  • J . Gen . Physiol .
  • 1997

ICln binds selectively to myosin light chain and a protein kinase

  • M. Saraste, P. R. Sibbald
  • Biophys . J .
  • 1997

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