Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient

@inproceedings{Lffler2016PersonalizedPV,
  title={Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient},
  author={Markus W. L{\"o}ffler and Premachandran Anoop Chandran and Karoline Laske and Christopher R. Schroeder and Irina Bonzheim and Mathias Walzer and Franz J. Hilke and Nico Trautwein and Daniel Kowalewski and Heiko Schuster and Marc G{\"u}nder and Viviana A. Carcamo Ya{\~n}ez and Christopher Mohr and M. M. Sturm and H Nguyen and Olaf Riess and Peter Bauer and Sven Nahnsen and Silvio Nadalin and Derek Zieker and Joerg Glatzle and Karolin Thiel and Nicole Schneiderhan-Marra and Stephan Clasen and Hans C B{\"o}sm{\"u}ller and Falko Fend and Oliver Kohlbacher and C{\'e}cile Gouttefangeas and Stefan Stevanovi{\'c} and Alfred Koenigsrainer and Hans-Georg Rammensee},
  booktitle={Journal of hepatology},
  year={2016}
}
BACKGROUND & AIMS We report a novel experimental immunotherapeutic approach in a patient with metastatic intrahepatic cholangiocarcinoma. In the 5year course of the disease, the initial tumor mass, two local recurrences and a lung metastasis were surgically removed. Lacking alternative treatment options, aiming at the induction of anti-tumor T cells responses, we initiated a personalized multi-peptide vaccination, based on in-depth analysis of tumor antigens (immunopeptidome) and sequencing… CONTINUE READING
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