Personalized medicine: genetic variation and loss of physiologic complexity are associated with mortality in 644 trauma patients.

@article{Norris2009PersonalizedMG,
  title={Personalized medicine: genetic variation and loss of physiologic complexity are associated with mortality in 644 trauma patients.},
  author={Patrick R. Norris and Jeffrey A. Canter and Judith M Jenkins and Jason H. Moore and Anna E Williams and John A Morris},
  journal={Annals of surgery},
  year={2009},
  volume={250 4},
  pages={524-30}
}
OBJECTIVE Personalized medicine merges genetics, physiology, and patient outcome. Loss of physiologic complexity (heart rate [HR] variability) is a bedside biomarker for autonomic nervous system (ANS) dysfunction. We hypothesized that variability in ANS receptor proteins (genetics) and loss of complexity (physiology) are independently associated with mortality in critical illness. SUMMARY BACKGROUND DATA Decreased HR complexity has been associated with increased mortality and morbidity in… CONTINUE READING