Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

@article{Sahin2017PersonalizedRM,
  title={Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer},
  author={Ugur Sahin and Evelyna Derhovanessian and Matthias Miller and Bjoern-Philipp Kloke and Petra Simon and Martin L{\"o}wer and Valesca Bukur and Arbel D. Tadmor and Ulrich Luxemburger and Barbara Schroers and Tana Omokoko and Mathias Vormehr and Christian Freire Albrecht and Anna Paruzynski and Andreas N. Kuhn and Janina Buck and Sandra Heesch and Katharina H. Schreeb and Felicitas Mueller and Inga Ortseifer and Isabel Vogler and Eva Godehardt and Sebastian Attig and Richard Rae and Andrea Breitkreuz and Claudia Tolliver and Martin Suchan and Goran Marti{\'c} and Alexander Hohberger and Patrick Sorn and Jan Diekmann and Janko Ciesla and Olga Waksmann and Alexandra-Kemmer Br{\"u}ck and Meike Witt and Martina Zillgen and Andree Rothermel and Barbara Kasemann and David Langer and Stefanie Bolte and Mustafa Diken and Sebastian Kreiter and Romina Nemecek and Christoffer Gebhardt and Stephan Grabbe and Christoph Hoeller and Jochen Utikal and Christoph Huber and Carmen Loquai and {\"O}zlem T{\"u}reci},
  journal={Nature},
  year={2017},
  volume={547},
  pages={222-226}
}
T cells directed against mutant neo-epitopes drive cancer immunity. However, spontaneous immune recognition of mutations is inefficient. We recently introduced the concept of individualized mutanome vaccines and implemented an RNA-based poly-neo-epitope approach to mobilize immunity against a spectrum of cancer mutations. Here we report the first-in-human application of this concept in melanoma. We set up a process comprising comprehensive identification of individual mutations, computational… CONTINUE READING
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