Personalized Prediction of Lifetime Benefits with Statin Therapy for Asymptomatic Individuals: A Modeling Study

@inproceedings{Ferket2012PersonalizedPO,
  title={Personalized Prediction of Lifetime Benefits with Statin Therapy for Asymptomatic Individuals: A Modeling Study},
  author={Bart S. Ferket and Bob J. H. van Kempen and Jan Heeringa and Sandra Spronk and Kirsten E. Fleischmann and Rogier L. G. Nijhuis and Albert Hofman and Ewout Willem Steyerberg and M G Myriam Hunink},
  booktitle={PLoS medicine},
  year={2012}
}
BACKGROUND Physicians need to inform asymptomatic individuals about personalized outcomes of statin therapy for primary prevention of cardiovascular disease (CVD). However, current prediction models focus on short-term outcomes and ignore the competing risk of death due to other causes. We aimed to predict the potential lifetime benefits with statin therapy, taking into account competing risks. METHODS AND FINDINGS A microsimulation model based on 5-y follow-up data from the Rotterdam Study… CONTINUE READING
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