Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease.

@article{DarNimrod2012PersonalityFM,
  title={Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease.},
  author={Ilan Dar-Nimrod and Benjamin P Chapman and Peter Franks and John Robbins and Anton P. Porsteinsson and Mark Mapstone and Paul R Duberstein},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year={2012},
  volume={20 12},
  pages={1026-35}
}
OBJECTIVES We tested the hypothesis that neuroticism moderates the association between APOE (apolipoprotein E) genotype and two major outcomes, cognitive function and Alzheimer disease. We also explored whether other personality dimensions (extraversion, openness to experience, agreeableness, and conscientiousness) moderate the associations of APOE with these outcomes. DESIGN Primary analyses of existing randomized clinical trial data. SAMPLE Six-hundred two older adults (mean age of 78… CONTINUE READING

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