Personality changes in Alzheimer's disease: a systematic review

@article{RobinsWahlin2011PersonalityCI,
  title={Personality changes in Alzheimer's disease: a systematic review},
  author={Tarja-Brita Robins Wahlin and Gerard J. Byrne},
  journal={International Journal of Geriatric Psychiatry},
  year={2011},
  volume={26}
}
People with Alzheimer's disease (AD) commonly exhibit changes in personality that sometimes precede the other early clinical manifestations of the condition, such as cognitive impairment and mood changes. Although these personality changes reflect the impact of progressive brain damage, there are several possible patterns of personality change with dementia. Early identification of personality change might assist with the timely diagnosis of AD. The objective of this study was to review studies… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Personality changes in Alzheimer's disease.
TLDR
Discriminant function analysis showed that the Global Deterioration Scale, the Clinical Rating Scale for Symptoms of Psychosis in Alzheimer's Disease, and the duration of dementia symptoms were the best predictors to classify personality change in an overall score of personality. Expand
Personality alterations in dementia of the Alzheimer type.
TLDR
It is demonstrated that patients with DAT become more passive, more coarse, and less spontaneous as a result of the disease. Expand
Caregiver ratings of personality change in Alzheimer's disease patients: a replication.
TLDR
These results strengthen the usefulness of caregiver ratings of personality change of patients with memory problems who cannot be useful informants on their own behalf. Expand
Primary Caregivers' Descriptions of Alzheimer Patients' Personality Traits: Temporal Stability and Sensitivity to Change
TLDR
The findings support the reliability of observer's descriptions of premorbid personality using the NEO-PI and the sensitivity of the instrument to personality change in dementia. Expand
Early Noncognitive Change in Alzheimer's Disease and Healthy Aging
TLDR
The results indicate that changes in behavior and personality can be reliably reported by family caregivers of patients with mild dementia. Expand
The Progression of Personality Changes in Senile Dementia of the Alzheimer's Type
TLDR
The presence of personality changes at a mild stage of dementia did not predispose subjects to more rapid progression to a more advanced stage of illness. Expand
Personality change in dementia of the Alzheimer's type: relations to caregiver personality and burden.
TLDR
Regression analyses indicated that present patient conscientiousness and caregiver neuroticism were the best predictors of both objective and subjective burden, and these variables were found to contribute independently to caregivers' reported level of burden. Expand
Carer‐rated personality changes associated with senile dementia
Although adult personality traits have been shown to be stable with age, a recent study in the USA showed changes in a group of elderly people with memory disorders, as perceived by caregivers. TheExpand
Life-span perspective of personality in dementia.
TLDR
The personalities of dementia patients seem to reflect adaptive patterns that served them in the past, and use of a life-span perspective of personality continuity can enhance individualized care for demented patients and advance theory development. Expand
Concordance between observers in descriptions of personality change in Alzheimer's disease.
TLDR
Both primary caregivers and others who know a patient well may serve as informants for studies of personality in dementia, and substantial agreement between independent raters is indicated. Expand
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