• Psychology, Medicine
  • Published in
    International journal of…
    2006
  • DOI:10.1002/gps.1545

Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.

@article{Ball2006PersonalityAB,
  title={Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.},
  author={Sarah L Ball and Anthony Holland and Johnny Hon and Felicia Huppert and Peter Treppner and Peter Watson},
  journal={International journal of geriatric psychiatry},
  year={2006},
  volume={21 7},
  pages={
          661-73
        }
}
BACKGROUND Research based on retrospective reports by carers suggests that the presentation of dementia in people with Down's syndrome may differ from that typical of Alzheimer's disease (AD) in the general population, with the earliest changes tending to be in personality or behaviour rather than in memory. This is the first long-term prospective study to test the hypothesis that such changes, which are more typical of dementia of frontal type (DFT) in the general population, mark the… CONTINUE READING

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